I6657

Image

1 of 1

Last 5 Products Viewed

I6657

Sigma

 

Itraconazole

≥98% (TLC)

Synonym:Oriconazole, R51211, Sporanox
CAS Number:84625-61-6
Linear Formula:C35H38Cl2N8O4
Molecular Weight:705.63
MDL number:MFCD00870168

Customers Also Purchased
F8929


Fluconazole
≥98% (HPLC), solid		K1003


Ketoconazole
≥98% (TLC)		T8826


Terbinafine hydrochloride
≥98%		A4888


Amphotericin B from Streptomyces sp.
~80% (HPLC), powder

Details

Related Products

References

Reviews

Description

Biochem/physiol ActionsSynthetic broad-spectrum triazole antifungal agent. Mode of action: Inhibits cytochrome P450 dependent enzymes including 14α-demethylase. The inhibition results in prevention of the biosynthesis of ergosterol, a critical fungal cell wall component.

Properties

assay≥98% (TLC)
solubilitychloroform: 50 mg/mL, clear, colorless
storage temp.2-8°C

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard CodesXi
Risk Statements36/37/38
Safety Statements22-26-36
WGK Germany3
RTECSXZ5481000

References

referenceChau, A.S., Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae. Antimicrob. Agents Chemother. 50, 3917-3919, (2006)
 Xiong, Q., et al., Cholesterol import by Aspergillus fumigatus and its influence on antifungal potency of sterol biosynthesis inhibitors. Antimicrob. Agents Chemother. 49, 518-524, (2005)
 Sabatelli, F., et al., In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts. Antimicrob. Agents Chemother. 50, 2009-2015, (2006)
 Vanden Bossche, H., et al., Effects of itraconazole on cytochrome P-450-dependent sterol 14α-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans. Antimicrob. Agents Chemother. 37, 2101-2105, (1993)
MerckMerck 14,5245